Acute effects of cigarette smoke on Endothelial Nitric Oxide synthase, vascular cell adhesion molecule 1 and aortic intima media thickness

Background. Cigarette smoking could induce endothelial dysfunction and the increase of circulating markers inflammation by activation monocytes. This can lead to increased intima media thickness (IMT) entire blood vessels result in acceleration atherosclerosis process. However, our knowledge, little is known about role cigarette this atherosclerotic inflammatory process. The aim study explore link between its effect on nitric oxide synthase (e-NOS) vascular cell adhesion molecule 1 (VCAM-1). Methods. An experimental with a post-test only controlled group design was used. We used 18 Wistar rats (Rattus norvegicus) randomly subdivided into two groups: K (-) were not exposed tobacco smoke, whereas (+) smoke equivalent more than 40 cigarettes for 28 days daily. After days, samples analyzed e-NOS, VCAM-1 aortic IMT. Results. Our results indicate that enhance expression rat cardiac cells, resulting decreased e-NOS level IMT. Linear regression model found eNOS negatively correlated wiith IMT (r2 = 0.584, ? -0.764, p < 0.001), did correlate 0.197, = 0.065). Conclusion. Low high observed after exposure which may IMT.